Synergistic antitumor interaction between valproic acid and capecitabine in breast cancer
نویسندگان
چکیده
منابع مشابه
Synergistic antitumor interaction between valproic acid and capecitabine in breast cancer
Capecitabine, commonly used in different settings for metastatic breast cancer, is an inactive prodrug that take advantage of the tumor elevated levels of thymidine phosphorylase (TP), a key enzyme for its conversion to 5-florouracil. Potentiation of anticancer activity of capecitabine is required to improve its therapeutic index. We demonstrated that histone deacetylase inhibitors (HDACi), inc...
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BACKGROUND Recurrence with distant metastases has become the predominant pattern of failure in locally advanced rectal cancer (LARC), thus the integration of new antineoplastic agents into preoperative fluoropyrimidine-based chemo-radiotherapy represents a clinical challenge to implement an intensified therapeutic strategy. The present study examined the combination of the histone deacetylase i...
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An 80-year-old woman with a weight of 74 kg had been primarily diagnosed with complex partial seizures secondary to severe cerebrovascular disease; she also had atrial fibrillation, peripheral artery disease, untreated high blood pressure, and advanced cognitive impairment – she only utters isolated words with a tendency to echolalia. She had an acute thromboembolic stroke two years ago, which ...
متن کاملThe correlation between telomerase activity and Bax/Bcl-2 ratio in valproic acid-treated MCF-7 breast cancer cell line
Objective(s):Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. Telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. A relation between telomerase activity and resistance to apoptosis has been established. T...
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Valproic acid and meropenam is commonly co-administrated in neurosurgical patients. Meropenem potentially decreases the valproic acid level, which may cause perioperative seizure. There has been no previous report of drug interaction between valproic acid and meropenem in Thailand. The authors report a patient who faced uncontrolled seizure after co-administrated valproic acid and meropenem. Th...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2015
ISSN: 2051-1426
DOI: 10.1186/2051-1426-3-s1-p4